Photo: Hummingbird Nano 10 um Diameter Circular Channel
When using live cells or other fragile molecules, every design consideration matters.
Design choices matter when you need better viability. That's why we re-examined sources of shear stress that contribute to cell mortality and particle damage. Not just on the chip, but outside of it. With our unique manufacturing method, we have opened new options for microfluidic users in single cell and extracellular vesicle analysis, fluid concentration, capillary electrophoresis, drug discovery and a variety of other applications.
Circular Channel Geometry
Channel geometry plays a significant role in the success of an assay. Non-circular cross-section geometries and corners induce stress on particles and are well-known sources for creating air bubbles which can negatively impact flow and potentially clog a channel. The smooth surfaces of a circular channel reduce turbulence and improve flow. Technology has not been available until now to be able to create circular channels in a polymer without bonding.
Novel manufacturing allows maximum flexibility in diameter, length, and dimension. Need a smaller channel - we can do submicron diameters for small particle separation and analysis. Need a taper or diameter variation over length - we can create a variety of prototypes for you to analyze for concentration or nanoparticle manipulation.
How the outside world interfaces with the chip can be critical to the success of an assay. For the least amount of stress, we have available a variety of standard side connect interface options that integrate directly into circular channels of any dimension. No sharp corners when introducing a sample into a microfluidic channel. Additionally with standard luers, you can achieve zero dead volume & minimal swept volume which can save up to tens or hundreds of thousands of dollars on reagents, depending on your testing volume.
Current microfluidic geometries limit discovery. Contact us to discuss how we can help unlock new insights or bring your concept to reality.